What makes Ebola so dangerous? How can a virus overwhelm the very complex defense system of the body so quickly and so effectively? Let’s take a look at what Ebola does. (Theme music) Ebola is a virus. A virus is a very small thing. A bit of RNA or DNA and a few proteins and a hull. It has no ability to do anything by itself whatsoever, and can only survive and proliferate by infecting cells. To avoid this we have the immune system. The immune system is super complex so we develop a visual system that makes it easy to understand. So it looks like this: Let’s concentrate on the part that is critical to understanding Ebola and ignore the rest. So usually dendritic cells will activate the army of anti-virus cells, support cells and anti-body factories that work together with the guard cells wipe out the infection in a matter of days. But when Ebola strikes, it directly attacks the immune system. Some of the first cells it takes over are the dendritic cells, the brains of the immune system. The Ebola virus enters a dendritic cell by binding into receptors for cell transport. Once it is inside, it dissolves its outer hull and releases its genetic material, nucleoproteins and enzymes. In a nutshell it takes over the cell, disables the cells protective mechanisms and reprograms it. The cell now becomes a virus production machine and uses its resources to build Ebola viruses. Once the cell is saturated, it dissolves the cell membrane and millions of viruses are released into the tissue. The virus not only prevents the dendritic cells from activating the specialized and anti-virus forces, it manipulates them into sending signal proteins that tricks specialized cells into ending their own life’s prematurely. So the immune system is seriously disrupted and unable to react. When the virus rapidly multiplies, we’re talking billions, there are cells that should deal with infected cells, the natural killer cells, but they also get infected and just die before they can prevent the disease from spreading. At the same time Ebola infects the guard cells of the body macrophages and monocytes, not only managing to circumvent their defenses, it also manipulates some to signal to the cells make up the blood vessels telling into release fluid into the body Usually this makes sense, but in this case it just causes mayhem. All of the body’s neutrophils are activated awaken by the virus and the macrophages signals then are not very effective against viruses and should not be involve in this fight and begin to do lots of stuffs they shouldn’t do. The neutrophils signals to the blood vessels to release more fluid causing internal bleeding. Another area of the body Ebola attacks is the liver. The virus finds it very easy to enter the liver and it quickly starts killing loads of liver cells and causing organ failure and more internal bleeding. And all those things are going on at the same time. As the virus spreads, it’s like nukes exploding every where. One incident of this in one region will be problem enough But now is starting to happen everywhere at once. All the mechanisms of the immune system have evolve to handle infections work against you. And the virus continues to spread and spread. And finally begins to infect more and more body cells while the body desperately struggles to stay alive. In a desperate last effort to turn the tide the immune system launches a cytokine storm. A cytokine storm is an S.O.S signal that causes the immune system to launch all of its weapons, all at once in a desperate kamikaze attack. This hurts the virus but leaves behind tons of collateral damage, Especially in the blood vessels. Paradoxically the healthier the immune system, the more damage it can do to itself More and more fluid leaves the blood stream. Blood pours after every opening of the body. You become seriously dehydrated that just not now blood left to supply the organs with oxygen and cells begin to die. If you reach this point the chance of you dying is very high. Currently six out of ten infected die from Ebola. Wow! Ok. Ebola is nasty. So it’s time to panic, right? No, not even close. The severity of Ebola gets paper sold and YouTube videos shared so everybody is talking about Ebola. But currently the only way to get infected by Ebola is to come into contact with the body fluids of a person who shows symptoms Or from infected bat. So just don’t do that. Ebola has killed 5,000 people since June 2014. The common flu kills up to 500,000 people each year. Malaria causes up to one million each year. 3,000 people every single day. Ten children since this video started. So even if Ebola is terrible and scary, don’t let yourself be scared. The most infectious thing about Ebola is the media hype around it. You could learn a bit more about the immune system though Transcription made by Miriam Delgado Subtitles by the Amara .org community Revised by: Ace Ervite
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Ebola exists
Knuckles:dO yoU kNoW tHe waY
Ebola:Oh no.
Just drink flex seal IM KIDDIND BTW
Ebola : take control of the entire immune system
Body : C O W A B O N G A I T I S
This is great BUT it needs more faces on things
I’ve never had a lot of anxiety after this
Edit: THANKS FOR THE ENDING I CURED MY EBOLA ANXIETY AFTER THIS VIDEO
Ebola is an American manufacture
Rabies has 99.99% of mortality rate.
So…
I don’t have Ebola? 🙂
Ebola is not dangerous it helps you to find the wae
1:20 FOR THE SWARM
頑張れ！ EBOLA CHAN !!
You can do it ebola chan! We believe in you!
한국인…?
5 years and that Virus Infection Video isn't here yet. Care to explain?
Of course Ebola will try to kill the body.
Instead of politely asking the virus to stop, the barbaric immune system acted with violence
Another deadly disease from Africa again?
I had Ebola before but luckily I survived
Ebola: I am winning!
The immune system: I'm gonna do what's called a pro gamer move
Ebola
To
Killed Human
To
Infector
To
Dead
To
Z
Zubat is dangerous?
Pokecenter is closed due to infected zubat attack
Dammit.Why do the natural killer cells go like, "sorry buddy, you have to die"! They're giving the immune system army a bad name.
4:32 Really no one saw "Is Moffat still in charge? I miss good episodes."?????
YOU ARE GOD DAMN RIGHT BRO!!! Like if you want Moffat as 14th
If its a virus why can't we install a anti-virus
Well boys we did it ebola is no more
A bowl of what?
ebola…welcome to America
can bacteriophage kill Ebola?
1:33 I like that star craft reference
Basically the pink corrution in your body-
ebola knos de wae
dis is da wae *click* *click* (sooooooooooooooorry i know this is a dead meme)
Suddenly, evolution
cat
Pode comentar em portugues ? Kkkkk
Kind of racist about the “white people infected now we better do something” part.
use phages!
Virgin killer T cell
Body cells: Immune cell!!!! You have became the very thing you swore to destroy! You're supposed to kill ebola not join them!!!
Infected Immune Cells: I HATE YOOOUUUU!!!!
Wait is that body war one or hitler look like ebolahitler
Zubat!
Timestamp 5:08
So.. if you have AIDS youre immune to Ebola..
How on Earth is this already 4 years ago. Man, time really flies by.
This is really cool
How about plague and all its forms? That could be an interesting subject each infection based on route of exposure and all that. Just a thought
Ebola detected
sends in banelings and all drones
that twist tho
Everyone who's played Plague Inc knows high mortality rate is will most likely eradicate the virus. Ebola is just plain dumb lmao.
FIRE ALL THE WEAPONS!
But sire, our cells!
DO IT
Media hypes Ebola?
I don't know about that. If people begin to get infected one after another in quick succession and there's no cure and die the most agonizing death, it is something to ponder. Just because Ebola hasn't crossed the vast oceans yet, doesn't mean everything will be fine.
If you have common sense, Ebola was fist seen in Zaire in 1976 and today, it crawled out to different African countries. And people who think they might have it have tried to escape health checkpoints.
The recent and ongoing outbreak in Congo, no one is really paying attention to it unless you look for the news.
It's almost like the virus has intelligence, it knows which cells to attack first and to trick others, it's scary
Kurzgesagt, How Did Ebola Infect Cells
And that's when the immune system knew
It had sponned
The joke is that a spoon is what Mumbo Jumbo calls a mistake, in this case the mistake kills you.
0:47 is this ebola travelling on the london underground or some shit
Virgin T cell: what are you oder commander?
Dendritic cell: execute order 66
ma lord
ma lady
malaria
Human immune system is just a crap cant fight against any infections
You forgot the part when you die knuckles goes to you and let you go to uganda land
Doctor Who cameo
How is this not a man-made disease?
Rip
so in nutshell the ebola fighting the immune system is like soviet vs germany
Cant we just like nuke Ebola???
0:23
(Bodybuilder enters the chat)
Virus: am i wrong to you?
what if you survive ebola are you IMMUNE to it?
immune system: we can TAKE ON THIS NEW VIRUS
EBOLA: we will see about that
immune system: were gonna win any ways
ebola: destroys immune system
immune system: we cant take it anymore were dead rip
EBOLA: ha ha now time to spread to another human
Fun fact- kursgesagt means "short" in Germany
Ebola: Comes back
Africa: Ah shit, here we go again
Malaria and plague:Are we a joke to you?!
Trump Cell:
I WILL BUILD A CE WALL
A CELL WALL
Powerful did malaria I'm going to do something dangerous when I'm old I'm going to go and visit western Africa and kill Ebola 🎉 for good😒
Ebola enters the chat
Veggies enters the chat
Ebola leaves the chat
Me got idea use 9999999999999999991 antibodies!
And 99999999999999×999999999999999999999999999999999999999 cell wall and B cell
Flu? Yuck!
How painful would that be to have bruises everywhere in your body?
Kill Ugandan knuckles!!!!
I agree that this is a series topic, I just wanted to make some people laugh 🙂
Ebola: Hahahah humans DIEEE!!!!
Bacteriophage: Hold my bacteria spaghetti
I actually though that thw ebola virus was
Medusa xD
But no joke this really is dangerous
PaArDriJdeN iS geEn SpOrT
O just need to feed myself to get my body resources to fight ebola hahaha
3:34 SARS and bird flu can also trigger that last-ditch kamikaze strike. The result's the same: The invader is beaten back, but it's a Pyrrhic victory for the immune system because of all the heavy collateral damage it leaves behind.
Hey VSauce , Micheal here. How would you like to be affected with ebola?
so if I don't have any wound on my skin, still can infect EBOLA? 0.0
It even looks cool on inverted color mode
We should make an vaccine against it and via the Crispr method we can separate the ebola gene code from our natural cells' genetic code, so by this . Those stupid ebola will die and we will be saved from its wrath…
this video is serously amazing! Good job
Why is Ebola not in the USA and the UK
when you are fighting as ebola and hear MY LIFE FOR AIUR
Indonesia sub is so broken
Ebola is serious
4:31 is zubat dangerious
Me: goes on pokemon go sees shiny zubat it escaped
Me: its dangerious it hurt my feelings
Yey zerg references 😂😂👌
4:43 what’s the white one?
Other hand made viruses started africa to reduce population
Remember when we started bringing infected mother fuckers over to the states? Because, yeah, let's take that risk so we all can die horribly.
Can Ebola cause liver cancer
Ebolalala
Nice inclusion of anti white bigotry. Yuck.
The StarCraft references are real
What about rabies?
But, what if the ebola virus infects the water of a city